PROTEASE RESISTANT MMUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE

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专利权人:

The Brigham and Womens Hopistal; Inc.

发明人:

Lee, Richard,Segers, Vincent

申请号：

AU2016216675

公开号：

AU2016216675A1

申请日:

2016.08.18

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

#$%^&*AU2016216675A120160908.pdf#####ABSTRACT The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-I to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.

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