KUHNERT, SVEN,MERLA, BEATRIX,BAHRENBERG, GREGOR,SCHRODER, WOLFGANG
申请号：
NZ59562810
公开号：
NZ595628A
申请日:
2010.03.11
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
The invention relates to substituted nicotinamides of general formula (1), in which A1 represents CR10R11 or S A2 represents CR12R13, C(=O), O, S, S(=O), or S(=O)2 R1 represents saturated or unsaturated, branched or linear, unsubstituted, monosubstituted, or polysubstituted C1-10-alkyl or C2-10-heteroalkyl saturated or unsaturated, unsubstituted, monosubstituted, or polysubstituted C3-10-cycloalkyl or heterocyclyl unsubstituted, monosubstituted, or polysubstituted aryl or heteroaryl saturated or unsaturated, unsubstituted, monosubstituted, or polysubstituted C3-10-cycloalkyl or heterocyclyl bridged by C1-8-alkyl or C2-8-heteroalkyl, wherein the alkyl chain or heteroalkyl chain can be branched or linear, saturated or unsaturated, unsubstituted, monosubstituted, or polysubstituted or unsubstituted, monosubstituted, or polysubstituted aryl or heteroaryl bridged by C1-8-alkyl or C2-8-heteroalkyl, wherein the alkyl chain or heteroalkyl chain can be branched or linear, saturated or unsaturated, unsubstituted, monosubstituted, or polysubstituted R9 represents saturated or unsaturated, unsubstituted, monosubstituted, or polysubstituted C3-10-cycloalkyl or heterocyclyl unsubstituted, monosubstituted, or polysubstituted aryl or heteroaryl or CRcRd. The invention also relates to methods for the production thereof, medicaments containing said compounds, and the use of said compounds for producing medicaments suited to treating pain, epilepsy, anxiety, dependency, mania, bipolar disorders, migraine, cognitive diseases, dystonia-associated dyskinesias and/or urinary incontinence. Examples of such compounds include: N-(3-Methyl-butyl)-2-[[1-methyl-3-[3-(trifluoromethyl)phenyl]-propyl]sulfanyl]-pyridine-3-carboxylic acid amide, 2-[3-(4-Fluorophenyl)-propylsulfanyl]-N-(2-methoxy-3,3-dimethyl-butyl)-pyridine-3-carboxylic acid amide, 2-[3-(4-Fluorophenyl)-propylsulfanyl]-N-[3-(1H-[1,2,4]triazol-1-yl)-propyl]-pyridine-3-carboxylic acid amide, 2-[3-(4-Fluorophenyl)-propylsulfanyl]-N-[(3
