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Indanyloxidihydrobenzofuranylacetic acids, useful for the treatment of metabolic syndrome
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
HIMMELSBACH, FRANK,BAKKER, REMKO,ECKHARDT, MATTHIAS,HAMPRECHT, DIETER,LANGKOPF, ELKE,WAGNER, HOLGER
申请号:
ES11788845
公开号:
ES2546154T3
申请日:
2011.11.30
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of formula (I): ** Formula ** in which: R1 is selected from the group consisting of H, F, Cl, Br, I, C1-8 alkyl, C2-6 alkenyl, C2-6 alkynyl , C3-12 cycloalkyl, C3-12 cycloalkyl-C1-4 alkyl, C5-12- bicycloalkyl, C5-12 alkyl-C1-6- alkyl, C5-6 cycloalkenyl, C5-6 cycloalkenyl-C1-4 alkyl, C1-alkyloxy -8, C3-6-oxycycloalkyl and C3-6-cycloalkylC 1-4 alkyloxy, where any of these groups is optionally and independently substituted with 1 to 3 fluorine atoms and / or 1 to 3 R4 groups, C3-12 heterocyclyl , C3-12 heterocyclyl-C 1-4 alkyl, bicycloheterocyclyl-, bicycloheterocyclyl-C 1-6 alkyl, heterocyclylC 1-4 alkyl and C 3-12 heterocyclyloxy, where any of these groups is optionally and independently substituted with 1 to 3 R 4 groups , aryl, arylC 1-4 alkyl, arylC 1-4 alkyl-oxy, aryloxy, heteroaryl, heteroaryl-C 1-4 alkyl, heteroaryl-C 1-4 alkyl and heteroaryloxy, where any of these groups is optionally and independently s used with 1 to 5 R5 groups, C1-4 alkyl sulfanyl, C1-4 alkyl sulfinyl and C1-4 alkyl sulfonyl, where any of these groups is optionally substituted with 1 to 3 fluorine atoms, and cyano, nitro, amino, C1-4 alkylamino and di- (C1-4 alkyl) -amino; where the heterocyclyl groups and sub-substances mentioned above may be partially unsaturated and comprise 1 to 3 heteroatoms or groups selected from N, NRN, O and S, with the proviso that only up to two of the heteroatoms are O and S, and not formed no OO, SS or SO bond, while a methylene group attached to a heteroatom can be replaced by a carbonyl group, while heterocyclyl groups are attached to the respective moiety through a carbon or nitrogen atom; RN represents H, C 1-4 alkyl, C 1-4 alkyl (O) - or C 1-4 alkyl (O) -, where the above-mentioned bicycloheterocyclyl groups and sub-substrates may be partially unsaturated and comprise from 6 to 12 ring members and 1 to 3 heteroatoms or groups selected from N, NRN, O and S, provided that only up to two of the heteroatoms are O and S, and no OO, SS or SO link is
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