The present invention is directed to methods and systems directed to altering the differentiation of a cell, more particularly to biasing a potent cell, such as a mesenchymal stem cell, by contacting such cell with a protein having properties of bone morphogenic protein-4. The contacting may be achieved via genetic modification, and the resulting cell may be or have characteristics of a pre-adipocyte. Pre-adipocyte cells so-obtained, and their progeny, may be used for various purposes, including in cosmetic and other surgical therapies and treatments.
