VALAMEHR, Bahram,BJORDAHL, Ryan,GOODRIDGE, Jode,LEE, Tom
申请号：
SG11202005173S
公开号：
SG11202005173SA
申请日:
2018.12.21
申请国别(地区):
SG
年份:
2020
代理人:
摘要：
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. The derivative cells provided herein have stable and functional genome editing that delivers improved or enhanced therapeutic effects. Also provided are therapeutic compositions and the used thereof comprising the functionally enhanced derivative effector cells alone, or with antibodies or checkpoint inhibitors in combination therapies.
