MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
发明人:
KREYSCH, HANS-GEORG
申请号：
CA2501821
公开号：
CA2501821C
申请日:
2003.10.09
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The invention relates to novel bispecific antibodies and their use in tumortherapy. The novel antibodies have the ability to bind to ErbB receptors,preferably ErbB1 receptors, which are overexpressed on many cancer tissues.Since the different specificities of the antigen-binding sites are directed todifferent epitopes within the binding domain of same or different ErbBreceptors, these antibodies are more effective with respect to inhibition anddown-regulation of the ErbB receptor and the corresponding signaling cascade.
