ROINESTAD, KURT,GUILFORD, WILLIAM,KIRKLAND, TOM,BHATT, LOPA,SPRINGMAN, ERIC
申请号：
CA3045887
公开号：
CA3045887A1
申请日:
2017.12.11
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
This present disclosure is directed to compounds of formula (I): (I) where R1a, R1b, R1c, R1d, R1e, R3, R4a, R4b, R4c, R4d, R6, R7, and R8 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof； which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions including the compounds described herein and methods of preparing the compounds described herein are also provided.
