Disclosed are systems, devices, and methods for navigating a tool inside a luminal network. An exemplary method includes receiving image data of a patient's chest (S302), identifying the patient's lungs (S304), determining locations of a luminal network in the patient's lungs (S306), identifying a target location in the patient's lungs (S312), generating a pathway to the target location (S314), generating a three-dimensional (3D) model of the patient's lungs (S308), the 3D model showing the luminal network in the patient's lungs and the pathway to the target location, determining a location of a tool (S318) based on an electromagnetic (EM) sensor included in the tool as the tool is navigated within the patient's chest, displaying a view of the 3D model showing the determined location of the tool (S320), receiving cone beam computed tomography (CBCT) image data of the patient's chest (S322), updating the 3D model based on the CBCT image data (S328), and displaying a view of the updated 3D model (S336).
