Compounds of benzodiazepine derivatives containing the inhibitory activity of A4 hydroxyl (Lat4H) leukemia, including their pharmacological components, are used to develop a drug for cardiovascular diseases, such as Aterosclerosis, myocardial infarction, Apoplejia, and aneurysms. Aorta, pulmonary hypertension, etc.
ZHANG, QIANG,ABEYWARDANE, ASITHA,BURKE, MICHAEL J.,KIRRANE, THOMAS MARTIN, JR.,NETHERTON, MATTHEW RUSSELL,PADYANA, ANIL KUMAR,SMITH KEENAN, NANA LOUISE,TAKAHASHI, HIDENORI,TURNER, MICHAEL ROBERT,ZHANG
申请号：
CL2013002546
公开号：
CL2013002546A1
申请日:
2013.09.04
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.COMPUESTOS DERIVADOS DE BENZODIOXANO CON ACTIVIDAD INHIBIDORA DE LEUCOTRIENO A4 HIDROLASA(LAT4H), COMPOSICION FARMACEUTICA QUE LOS COMPRENDE, USO PARA PREPARAR UN MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES TALES COMO ATEROESCLEROSIS, INFARTO DE MIOCARDIO, APOPLEJIA, ANEURISMA DE AORTA, HIPERTENSION PULMONAR ARTERIAL, ENTRE OTRAS.
