The application describes a complex that contains, as a first component, a component derived from an antibody that specifically binds to a target antigen, and as a second component, a peptide derived from a virus bound to a protein complex of the MHC class. Using the complex described in the present description, existing individual virus-specific circulating cytotoxic T cells (memory T cells and / or effector T cells) of an individual can be directed to cells expressing a target antigen with which the complex component derived from the antibody specifically binds, "labeling "these cells are HCH class I complexes, mimicking an acute viral infection. So, one of the objects of the invention is a complex, characterized in that it contains one fused polypeptide, which contains in the direction from the N- to the C-terminus or (I) β2-microglobulin and (II) extracellular domains α1, α2 and α3 of the MHC molecule class I, the relative frequency of occurrence of which is less than 1%, or (I) a peptide derived from the virus, (II) β2-microglobulin and (III) extracellular domains α1, α2 and α3 of the MHC molecule of class I, the relative frequency of occurrence of which is 1% or more, and two polypeptide chains that are linked using one and whether there are several disulfide bridges in which the first polypeptide chain linked by disulfide bridges contains from the N- to the C-terminal end (I) the variable domain of the immunoglobulin light or heavy chain, (II) the constant domain of the immunoglobulin light or heavy chain and (III) the hinge polypeptide an antibody chain region, and a second polypeptide chain linked by disulfide bridges contains an antibody heavy chain hinge polypeptide,В заявке описан комплекс, который содержит в качестве первого компонента выведенный из антитела компонент, который специфически связывается с антигеном-мишенью, и в качестве второго компонента выведенный из вируса пептид, связанный с белковым комплексом ГКГС класса. С помощью представленного в
