NICHOLSON, Michael, G.,MACLEOD, Daniel, T.,ANTONY, Jeyaraj,BARTSEVICH, Victor,JANTZ, Derek,SMITH, James, Jefferson
申请号：
DK16782371
公开号：
DK3359184T3
申请日:
2016.10.05
申请国别(地区):
DK
年份:
2020
代理人:
摘要：
Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous T cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.
