The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
Hinrichs, Christian S.,Rosenberg, Steven A.
申请号：
AU2019283892
公开号：
AU2019283892A1
申请日:
2019.12.18
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2019283892A120200123.pdf#####ABSTRACT OF THE DISCLOSURE Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E7, E711-19. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.
