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"recombinant modified vaccinia ankara (mva) vaccinia virus containing restructured insertion sites"
专利权人:
发明人:
MOSS BERNARD,WYATT LINDA S,EARL PATRICIA L
申请号:
IN4311/DELNP/2012
公开号:
IN2012DN04311A
申请日:
2012.05.16
申请国别(地区):
IN
年份:
2015
代理人:
摘要:
The present invention relates to recombinant modified vaccinia Ankara (MVA) virus containing restructured sites useful for the integration of heterologous nucleic acid sequences into an intergenic region (IGR) of the virus genome, where the IGR is located between two adjacent, essential open reading frames (ORFs) of the vaccinia virus genome, wherein the adjacent essential ORFs are non-adjacent in a parental MVA virus used to construct the recombinant MVA virus, and to related nucleic acid constructs useful for inserting heterologous DNA into the genome of a vaccinia virus, and further to the use of the disclosed viruses as a medicine or vaccine.
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