An orthodontic appliance for realigning one or more teeth in the intra oral cavity of a subject, includes a base having formed therein one or more guiding cells arranged to fit over a preselected tooth sought to be realigned from an initial position to a final position, each said guiding cell including a guiding structure defining a predetermined trajectory specific to the preselected tooth, along which the tooth is sought to be moved from the initial position thereof to the final position thereof； and apparatus, arranged within each guiding cell, for urging a predetermined tooth along its trajectory.
