An apparatus for the removal of needles (2) of syringes (3) is provided with two gripping devices (12, 19) adapted to withhold a syringe (3) and the respective needle (2), respectively, and an actuating device (21) for moving the two gripping devices (12, 19) with respect to each other with a roto-translating motion about and along a longitudinal axis (10) of the syringe (3) in order to unscrew the needle (2) from the syringe (3) itself.