The present invention relates to a composition comprising a) Streptomyces microflavus strain NRRL B-50550 and/or a mutant thereof having all the identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens and/or a mutant thereof having all the identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens and b) at least one further biological control agent selected from specific microorganisms and/or a mutant of it having all identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.Una composición que comprende a) cepa NRRL B-50550 de Streptomyces microflavus y/o un mutante de la misma que tenga todas las características que identifican a la cepa respectiva, y/o por lo menos un metabolito producido por la cepa respectiva que presenta actividad contra insectos, ácaros, nematodos y/o fitopatógenos y/o un mutante de la misma que tenga todas las características que identifican a la cepa respectiva, y/o por lo menos un metabolito producido por la cepa respectiva que presenta actividad contra insectos, ácaros, nematodos y/o fitopatógenos y b) por lo menos un agente de control biológico adicional seleccionado entre microorganismos específicos y/o un mutante de los mismos que tenga todas las características que identifican a la cepa respectiva y/o por lo menos un metabolito producido por la cepa respectiva que presente actividad contra insectos, ácaros, nematodos y/o fitopatógenos, e
