COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人:
Denis Le Bihan
申请号：
US15316474
公开号：
US20170146629A1
申请日:
2015.06.09
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A method to quantify and map iron deposits in the brain with diffusion-weighted magnetic resonance imaging (MRI) is based on the differential sensitivity of mono-polar (MPG) gradient pulse diffusion sequences and bipolar (BPG) sequences on the local magnetic field gradients induced by iron deposits and their cross-term with the diffusion-encoding gradients. The method comprises the steps of acquiring (12, 14) first MRI images and second MRI of a Region Of Interest by using MPG and BPG sequences, providing (16) an attenuation model of the diffusion MRI attenuated signal representative of the observed tissue, estimating (18, 20) a first apparent diffusion coefficient ADCMPG and a second apparent diffusion coefficient ADCBPG by fitting the MRI images with the attenuation model, calculating (22) a an iron induced local gradient factor ξFe as (Formula I) (I), and determining (24) the concentration [Fe] and/or the amount of iron stored in the local zone of the tissue from the calculated iron induced local gradient factor ξFe. An apparatus is configured for implementing such a method.
