FUNDACIÓN PEDRO BARRIÉ DE LA MAZA, CONDE DE FENOSA;UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
发明人:
OTERO CASAL, ANA MARÍA,ROMERO BERNÁRDEZ, MANUEL,MAYER MAYER, CELIA
申请号：
EP14822500
公开号：
EP3020814A4
申请日:
2014.07.10
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The invention relates to the cloning, sequencing and characterization of the gene responsible for Quorum Quenching (QQ) activity against Quorum Sensing (QS) signals of the Tenacibaculum sp. strain 20J (CECT7426). Said gene encodes a peptide having at least lactonase activity with a percentage of identity less than 38% with the lactonases described up until now for other species, as well as the sequences of the homologous genes present in other species of the genus Tenacibaculum. Said peptide shows a broad spectrum of activity degrading optionally substituted N-acyl-homoserine lactones (AHLs) of 4-14 carbon atoms in the side chain thereof, is active at pH comprised between 3 and 9, proteinase K- and chymotrypsin-resistant and does not interact with ²-lactam antibiotics.
