The present invention discloses a second use of lotus extract, which can effectively inhibit the inflammation factor in the blood, improves the activity of anti-oxidation enzymes and reduces the oxidative stress of the kidney, so as to achieve the functions of protecting the kidney and treating and preventing kidney diseases. Furthermore, the lotus extract is obtained from lotus through water extraction. The kidney diseases refer to diseases related to renal fibrosis, diseases related to kidney inflammation, chronic renal failure, or gouty kidney pathology.本發明係揭露蓮蓬萃取物之第二用途,其能夠有效地抑制血液中發炎因子、提昇抗氧化酵素活性、降低腎臟氧化壓力,據此達到保護腎臟及治療、預防腎臟疾病之功效。