The present invention relates to a composition for the prophylaxis and treatment of muscle-related diseases containing fresh vinegar extract or a compound isolated therefrom as an active ingredient. (1) Significantly increased MyoD transcriptional activity and differentiated it through (1) MyoD transcriptional activity evaluation method (Experimental Example 1), which measures myoD transcriptional activity of the fresh vinegar extract of the present invention. It was found to promote MHC expression in C2C12 cells； (2) Effect on myoblast differentiation The number of cylinder-shaped multinucleated myotubes was increased by sample processing through experiments (Experimental Example 2), and multinucleated myotubes ( Increasing the ratio of multinuclear myotubes, it has been proved to promote myoblast differentiation to form myotubes, the results of the above experiments showed that the extract of the present invention is atony, muscle atrophy, muscular dystrophy By confirming that the composition can be used as a therapeutic agent or adjuvant for muscle diseases such as muscle dystrophy, muscle degeneration, myopathy, atrophic atrophy, ataxia, cachexia and sarcopenia, the composition can be used for the prevention and It can be usefully used as a therapeutic pharmaceutical composition, health functional food and health supplement food.본 발명은 신선초 추출물 또는 이로부터 분리된 화합물을 유효성분으로 함유하는 근육관련 질환의 예방 및 치료용 조성물에 대한 것이다. 본 발명의 신선초 추출물을 대상으로 (1) myoD 전사활성(transcriptional activity)을 측정하는 근원세포의 분화촉진 효능 평가법(실험예 1)을 통하여 MyoD 전사 활성(transcriptional activity)을 유의적으로 증가시키고 분화된 C2C12 세포에서의 MHC 발현을 촉진함을 확인하였으며； (2) 근원세포 분화(myoblast differentiation) 에 미치는 영향 실험 (실험예 2)을 통하여 시료 처리에 의하여 실린더 형(cylinder-shaped) 다핵성 근관세포(multinucleated myotubes) 수를 증가시켰고, 다핵성 근관세포 (multinuclear myotubes)의 비율을 증가시켜, 근관세포를 형성하는 근원세포 분화를 촉진시킴을 입증하였는 바, 이러한 상기 실험 결과는 본 발명의 신선초 추출물이 긴장감퇴증(atony), 근위축증(muscular atrophy), 근이영양증(muscular dystrophy), 근육 퇴화, 근경직증, 위축성 축삭경화증, 근무력증, 악액질 (cachexia) 및 노인성근육감소증(sarcopenia) 등의 근
