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EGFR and PAR2 Regulation of Intestinal Permeability
专利权人:
Alessio Fasano
发明人:
Alessio Fasano,Karen Manon Lammers,Terez Shea-Donohue,Simeon Goldblum,Craig Sturgeon
申请号:
US13323100
公开号:
US20120107329A1
申请日:
2011.12.12
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides methods for diagnosing and treating an immune-mediated disease, e.g., an autoimmune disease, an allergy or an inflammatory disease. Diagnosis is made by detecting a heterozygous or homozygous genotype of haptoglobin 2 or by detecting and quantifying pre-haptoglobin 2 mRNA or protein. After diagnosis, the disease may be treated by decreasing cell permeability leading to increased transepithelial electrical resistance, for example, by administering an antibody directed against single chain zonulin thereby inhibiting epidermal growth factor receptor and inhibiting proteinase-activated receptor 2 (PAR2).
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