A method for the production of freeze-dried pellets comprising factor VIII comprises the steps of:a) freezing droplets of a solution comprising factor VIII to form pellets；b) freeze-drying the pellets；wherein in step a) the droplets are formed by means of droplet formation of the solution comprising factor VIII into a cooling tower which has a temperature-controllable inner wall surface and an interior temperature below the freezing temperature of the solution and wherein in step b) the pellets are freeze-dried in a rotating receptacle which is housed inside a vacuum chamber.
