The invention relates to a system for estimating glucose in plasma, comprising: a sensor that generates a signal from a concentration of glucose measured in a medium, filtering means, and a glycemic estimator. The invention also relates to a method comprising the following steps consisting in: i) generating a signal that represents the concentration of glucose measured in the medium； ii) filtering the signal generated； iii) applying a set of local estimation models to the aforementioned signal, thereby obtaining a set of local glucose-in-plasma estimations； iv) applying a weighting to each of the local estimations obtained； v) estimating a concentration of glucose in plasma by adding together the weighted local estimations obtained in the previous step； and vi) correcting the signal obtained in the preceding step using blood sugar reference measurements, and obtaining the final glucose-in-plasma estimation.
