<;P>;PROBLEM TO BE SOLVED: To find a method of highly utilizing an effective component taken out of the shellfish meat of Pinctada fucata martensii which has not been utilized that much. <;P>;SOLUTION: The hemolymph existing in the shellfish meat of Pinctada fucata martensii generated in pearl culture is found very effective for the skin, and the hemolymph is found very effective as an active ingredient of a skin external preparation. Particularly, the hemolymph obtained from the adductor muscle of Pinctada fucata martensii has been effective. <;P>;COPYRIGHT: (C)2011,JPO&INPIT