The present disclosure relates to topical compositions comprising a dermo-muscle relaxant, and optionally, one or more topical anesthetics or analgesics； a vitamin B3 compound； and/or a pharmaceutically acceptable plant extract. In some embodiments, the composition includes about 10% to about 20% w/w of the composition of the dermo-muscle relaxant. In some embodiments, the composition further includes about 1% to about 10% w/w of the composition of the topical anesthetic, topical analgesic, or a combination thereof. In some embodiments, the composition further includes a pharmaceutically acceptable base. In some embodiments, the pharmaceutically acceptable base comprises about 35% to about 95% w/w of the composition of a pharmaceutically acceptable oil, about 5% to about 25% w/w of the composition of a pharmaceutically acceptable wax, or a combination thereof. Such compositions are useful for treating anal fissure and cuts, abrasions, injuries, burns, and/or breakages on the skin.
