INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
INNES, Roger William,HELM, Matthew David
申请号：
WO2018US25511
公开号：
WO2018187182(A1)
申请日:
2018.03.30
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
Compositions, systems and methods are provided for conferring disease resistance to plant pathogens that use proteases to target plant substrate proteins inside plant cells. Briefly, the compositions, systems and methods are based upon plant substrate proteins that are targeted by pathogen-specific proteases and that activate nucleotide binding site-leucine rich repeat (NB-LRR) disease resistance proteins when cleaved by the protease. These substrate proteins are modified such that the endogenous protease recognition sequence is replaced by a protease recognition sequence specific to a different pathogen protease (i.e., a heterologous protease recognition sequence). The modified plant substrate protein therefore can be used in connection with its corresponding NB-LRR protein to activate resistance in response to cleavage by the heterologous pathogen-specific protease. When activated by the plant pathogen-specific protease, the pair initiates host defense responses thereto, including programmed cell death.
