The present invention relates to the reduction of flaky aggregation in nanoparticulate compositions. Nanoparticulate active agent, one surface stabilizer, and included in the present invention are compositions comprising (for example, sugar and buffer) flaky aggregation reducing agent. The nanoparticulate active agent composition comprises particles of active agent having an effective average particle size of less than about 2000nm. [Selection] Figure Figure 1本発明はナノ粒子組成物におけるフレーク状凝集の軽減に関する。ナノ粒子活性物質、少なくとも1つの表面安定剤およびフレーク状凝集軽減剤(例えば、バッファーおよび糖)を含む組成物も本発明に含まれる。該ナノ粒子活性物質組成物は、約2000nm未満の有効平均粒径を有する活性物質の粒子を含む。【選択図】図1
