Inhibitory oligonucleotide and use thereof

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专利权人:

发明人:

ESASHI EIJI,WANG LIYING,YU YONGLI

申请号：

IN4648/DELNP/2015

公开号：

IN2015DN04648A

申请日:

2015.05.29

申请国别(地区):

IN

年份:

2015

代理人:

摘要：

The inhibitory oligonucleotides (ODNs) which strongly block NF ? B activation induced by TLR9 agonists and TLR7 agonists are provided. The production of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor alpha is inhibited by the inhibitory ODNs. Interferon production from human PBMC induced by TLR9 agonist is prevented by the inhibitory ODNs. These ODNs can be used as a remedy for the treatment of immune mediated disorders such as rheumatoid arthritis systemic lupus erythematosus (SLE) sepsis multiple organ dysfunction syndromes.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/