The inhibitory oligonucleotides (ODNs) which strongly block NF ? B activation induced by TLR9 agonists and TLR7 agonists are provided. The production of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor alpha is inhibited by the inhibitory ODNs. Interferon production from human PBMC induced by TLR9 agonist is prevented by the inhibitory ODNs. These ODNs can be used as a remedy for the treatment of immune mediated disorders such as rheumatoid arthritis systemic lupus erythematosus (SLE) sepsis multiple organ dysfunction syndromes.
