Inhibitory oligonucleotides and uses thereof

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专利权人:

ＳＢＩバイオテック株式会社;SBIバイオテック株式会社

发明人:

江指 永二,ワン リーイン,ユー ヨンリー

申请号：

JP2015544288

公开号：

JP6106280B2

申请日:

2012.11.29

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The inhibitory oligonucleotides (ODNs) which strongly block NF-κB activation induced by TLR9 agonists and TLR7 agonists are provided. The production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor alpha, is inhibited by the inhibitory-ODNs. Interferon production from human PBMC induced by TLR9 agonist is prevented by the inhibitory-ODNs. These ODNs can be used as a remedy for the treatment of immune-mediated disorders such as rheumatoid arthritis, systemic lupus erythematosus (SLE), sepsis, multiple organ dysfunction syndromes.

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中国工程科技知识中心

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