Closed-system manufacturing process for CAR-T cells

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专利权人:

Seattle Children's Hospital (DBA Seattle Children's Research Institute)

发明人:

JENSEN, Michael C.,GUSTAFSON, Joshua

申请号：

AU2019217363

公开号：

AU2019217363A1

申请日:

2019.02.04

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

Some embodiments provided herein relate to methods and compositions for making genetically modified T cells. In some such embodiments, CD4+ and CD8+ T cells are cultured in a single serum-free volume. In some embodiments, co-cultured CD4+ and CD8+ T cells can be transduced with a lentiviral vector, and a population of transduced T cells can be harvested within a shorter period of time than other conventional methods.

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