The present invention addresses the problem of identifying a protein essential for plasmodium in a liver-infection stage to proceed to the next stage, pro viding a test method for searching for a compound obstructing this prote in, and providing a compound for hindering infection with plasmodium by obstructing the protein. The objective is achieved by a method of testing a subst ance for hindering infection with plasmodium, the test method being characterized in that an evaluation is made of whether or not merozoite formation in a liver stage of infection with plasmodium is obstructed by restraining action of LS-specific protein 2 (LISP2) in which plasmodium is specifically ex pressed in host cells in the middle to the latter period of the liver stage.
