COMPOSITIONS AND METHODS RELATING TO HINDERING DOT1L RECRUITMENT BY MLL-FUSION PROTEINS

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专利权人:

发明人:

Zaneta Nikolovska-Coleska,Chenxi Shen,Jay Hess

申请号：

US14763596

公开号：

US20150368300A1

申请日:

2014.02.14

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The present invention relates to MLL fusion proteins (e.g., AF9 and ENL), which activate target genes in part via recruitment of histone methyltransferase DOT1L. In particular, the present invention provides the AF9/ENL binding site in DOT1L and agents that block the protein-protein interactions between AF9/ENL and DOT1L, therefore inhibiting the activity of DOT1L, and inhibiting MLL-fusion protein associated leukemia.

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中国工程科技知识中心

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http://www.ckcest.cn/home/