Macrocyclic compounds with heterocyclic P2 'groups as factor Xia inhibitors农业专利-农业学术服务平台

发明人:: J．R．科尔特,J．R．科爾特,I．德卢卡,I．德盧卡,方天安,杨武,楊武,王裕丰,王裕豐,A．K．迪尔格,A．K．迪爾格,K．B．帕比塞蒂,W．R．尤因,朱晔恒,朱曄恒,R．R．韦克斯勒,R．R．韋克斯勒,D．J．P．品托,M．J．奥瓦特,M．J．奧瓦特,利昂．M．史密斯二世

摘要：: The invention provides a compound of formula (I) or its stereoisomer, tautomer or medicinal salt, wherein all variables are defined herein. These compounds are selective factor Xia inhibitors or double inhibitors of fxia and plasma kallikrein. The invention also relates to a pharmaceutical composition comprising these compounds and a method for treating thromboembolic and / or inflammatory diseases using the same.本發明提供式(I)化合物或其立體異構體、互變異構體或藥用鹽，其中所有變量均如本文中所定義。這些化合物爲選擇性因子XIa抑制劑或FXIa及血漿激肽釋放酶的雙重抑制劑。本發明還涉及包含這些化合物的藥物組合物及使用其治療血栓栓塞性和／或炎性病症的方法。