Disclosed is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3Kβ related disorders or diseases by using the compound disclosed herein.公開了式(I)的化合物或其立體異構物或其醫藥上可接受的鹽,以及包含式(I)的化合物或其立體異構物或其醫藥上可接受的鹽的醫藥組合物。還公開了通過使用本文公開的化合物治療PI3Kβ相關障礙或疾病的方法。