Based on the anti-ICAM3 antibody obtained by immunizing mice with BaF3 cells with high expression of ICAM3 artificially, it exerts cytotoxic effects on both hematopoietic cancer cell lines with both growth inhibitory activity and ADCC activity. We have succeeded in preparing a chimeric antibody that exhibits tumor reduction activity in vivo.ICAM3を人工的に高発現させたBaF3細胞をマウスに免疫して得た抗ICAM3抗体を基に、血液癌細胞株に対し、増殖抑制活性とADCC活性の双方で細胞傷害作用を発揮し、in vivoにおいて腫瘍縮小活性を発揮するキメラ抗体を調製することに成功した。
