The present invention aims to provide a STAT3 / 5 activation inhibitor. The present invention have the general formula In the formula, X 1 is a group -CH = or nitrogen atom. R 1 is a group -Z-R 6. Z is a group -CO-, based -CH (OH) - single ring nitrogen atom, of 5 to 15 members that have from one to four oxygen atom or a sulfur atom, R 6 is, ternary or binary ring, etc. I shows a saturated or unsaturated heterocyclic group ring. R 2 represents a hydrogen atom or a halogen atom. Y is a group -O-, based -CO-, based -CH (OH) - shows, a lower alkylene group or the like. A is a group I show etc.. R 4 represents an imidazolyl lower alkyl group, p is 1 or 2, a hydrogen atom, a lower alkoxy group such as R 3. To provide a STAT3 / 5 activation inhibitor containing a salt thereof as an active ingredient or an aromatic compound represented by].本発明は、STAT3/5活性化阻害剤を提供することを課題とする。本発明は、一般式[式中、X1は、窒素原子又は基-CH=を示す。R1は、基-Z-R6を示す。Zは、基-CO-、基-CH(OH)-等を、R6は、窒素原子、酸素原子又は硫黄原子を1~4個有する5~15員の単環、二項環又は三項環の飽和又は不飽和複素環基を示す。R2は、水素原子又はハロゲン原子を示す。Yは、基-O-、基-CO-、基-CH(OH)-、低級アルキレン基等を示す。Aは、基等を示す。R3は水素原子、低級アルコキシ基等を、pは1又は2を、R4はイミダゾリル低級アルキル基等を示す。]で表される芳香族化合物又はその塩を有効成分として含有するSTAT3/5活性化阻害剤を提供する。
