AUXOTROPHIC, RECOMBINANT BCG STRAIN PASTEUR AND USE THEREOF FOR COMBATING HUMAN INFECTIONS CAUSED BY PARASITES

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专利权人:

FUNDACAO OSWALDO CRUZ

发明人:

TENDLER, MIRIAM,ARMOA, GERALDO RODRIGUES GARCIA,SIMPSON, ANDREW, J

申请号：

NZ59566210

公开号：

NZ595662A

申请日:

2010.03.10

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

Disclosed is a recombinant BCG vaccine strain of Mycobacterium bovis that expresses the Sm14 antigen of Schistosoma mansoni (BCGr Pasteur ?LeuD/p?K410-hsp60*-Sm14). The vaccine strain according to the present invention is used for combating infection by parasites, particularly Schistosoma mansoni. The vaccine strain is a leucine-auxotrophic strain derived from the BCG substrain Pasteur, supplemented for leucine after genetic transformation with the construct p?K410-hsp60*-SM14. The effectiveness of the BCGr Pasteur ?LeuD/p?K410-hsp60*-Sm14 strain for combating Schistosoma mansoni infection by expressing the recombinant Sm14 antigen in vivo is demonstrated in the present invention.

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