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נוגדנים לאנטיגן ספציפי של קרום תאי הערמונית והשימוש בהם
专利权人:
CORNELL RESEARCH FOUNDATION INC.
发明人:
申请号:
IL20127409
公开号:
IL201274A
申请日:
2009.10.01
申请国别(地区):
IL
年份:
2015
代理人:
摘要:
Modified antibodies, or antigen-binding fragments thereof, to the extracellular domain of human prostate specific membrane antigen (PSMA) are provided. The modified anti-PSMA antibodies, or antigen-binding fragments thereof, have been rendered less immunogenic compared to their unmodified counterparts to a given species, e.g., a human. Pharmaceutical compositions including the aforesaid antibodies, nucleic acids, recombinant expression vectors and host cells for making such antibodies and fragments are also disclosed. Methods of using the antibodies of the invention to detect human PSMA, or to ablate or kill a PSMA-expressing cell, e.g., a PSMA-expressing cancer or prostatic cell, either in vitro or in vivo, are also provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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