A compound of formula (I) or a pharmaceutically acceptable salt thereof is provided. In formula (I), Ar is indazole, 5-isoquinoline, 6-isoquinoline, or their N-oxide. X is —；C(═；Z)—；, wherein Z is N—；CN, NH, NR4, NCOR4, NCONR4R5, NCO-aryl, S, or O. Y and J are independently H, alkyl, aryl, aminoalkyl, —；NH2, —；CN, —；OH, —；O-alkyl, —；O-aryl, —；COOH, —；COOR4, —；CONHR4, —；CONHCH2-aryl, —；CONR4CH2-aryl, —；NHCOR4, halogen, halogened alkyl, -alkyl-OR4, -alkyl-ONO2, alkyl-ONO2, —；OCOOR4, —；O(C═；O)-aryl, —；CHR4OH, —；CH2OH, —；CH2O(C═；O)-aryl, —；CH2O(C═；O)—；R4, —；CHR4O(C═；O)-aryl, —；CHR4O(C═；O)—；R4, unsaturated carboxylic ester, substituted alkynyl, —；NHSO2R4, —；SO2R4, —；SO2NHR4, or —；SO2NR4R5, or Y and J bond together to form a carbocylic or aromatic ring, wherein R4 and R5 are independently H, substituted C1-C6 alkyl, substituted aryl, cycloalkyl, alkylaryl, -alkyl-NR6R7, —；S(O)0-2-(alkyl-NR6R7). R1, R2 and R3 are H, C1-C6 alkyl, cycloalkyl, aryl, alkylaryl, alkylheteroaryl, alkylheterocycle, wherein any one thereof is optionally substituted with one or more of OH, NO2, or NR8R9.
