WU, HAN CHUNG,吴汉忠,吳漢忠,LIN, CHIN TARNG,林钦塘,林欽塘,LEE, TONG YOUNG,李冬阳,李冬陽,KUO, SZU YAO,郭思尧,郭思堯
申请号：
TW096119331
公开号：
TWI365748B
申请日:
2007.05.30
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
This Hair is bright provide ?Broken and control nucleic acid that the Should of Treatment uses in terms of withing, win peptide He Kang Body. The Guide of aforementioned victory peptide to mesh Standard be new vessels, and can be fixed by Sheng Wu Body Inner Shi Jun Body Cheng Now Ji Intraoperative Come Jia Yi Monitoring. This Class wins the new vessels of the distinguishable SCID little Shu Body Inner Duo Seed Swollen tumors of peptide SP5-52, but normal its non-Guide of Xue Guan And is to mesh Standard. The Xue Guan Knot of aforementioned victory peptide Yi Ke With people Class lung cancer Huo Body slice Sample sheets are closed. It include that SP5-52 With Doxorubicin Zhi Quality Body Hui increase with SCID mice the effect of Right Kang Duo Seed people Class cancer Iso Seed grafts.本發明提供了在診斷和治療之應用方面使用的核酸、胜肽和抗體。前述胜肽之導向目標是新生血管,且可藉由生物體內噬菌體呈現技術來加以鑑定。此類胜肽SP5-52可分辨SCID小鼠體內多種腫瘤的新生血管,但正常血管並非其導向目標。前述胜肽亦可與人類肺癌活體切片樣本之血管結合。包含SP5-52與多柔比星之脂質體會增加在SCID小鼠身上對抗多種人類癌症異種移植物的功效。
