БАЭЛЛ Джонатан Байлдон (AU),БУЙ Чинх Тхиен (AU),КОЛМЕН Питер (AU),ДАДЛИ Данетт А. (US),ФЭЙРБРАЗЕР Уэйн Дж. (US),ФЛАЙГЭР Джон А. (US),ЛЕССИН Гийом Лоран (AU),НДУБАКУ Чуди (US),НИКОЛАКОПУЛОС Джордж (AU)
申请号：
RU2011129789/04
公开号：
RU2011129789A
申请日:
2009.12.17
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. The compound of formula I or a pharmaceutically acceptable salt thereof, in which R independently represents a member selected from the group consisting of C1-6alkyl, C1-6 heteroalkyl, C1-6alkenyl, C1-6alkynyl, C1-4 haloalkyl and halogen； the subscript n means an integer from 0 to 2, and when n = 0, then X stands for -CH-, -C (H) (R) - or -C (R)； X stands for a member selected from the group consisting of - CH -, - C (H) (R) -, -C (R), -O-, -N (H) -, -N (R) -, -N (C (O) R) -, -N (C (O) OR) -, -N (S (O) R) -, -N (S (O) R) -, -S-, -S (O) -, -S (O) -, in wherein R is selected from the group consisting of C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-4 haloalkyl, Cycloalkyl and halogen； X, X and X are each independently selected from the group consisting of C (H), C (R) and N, with at least one from X and X denotes C (H) or C (R)； and wherein R is independently selected from the group consisting of -OR, -NRR, -SR, -C (O) OR, -C (O) NRR, -NRC (O) R, -S (O) R, -S (O ) R, —S (O) NRR, —R, halogen, —CN and —NO, wherein R and R are each independently selected from the group consisting of hydrogen, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-4haloalkyl, or, if necessary, R and R together with the atom to which each of them is attached form a 3-7-membered heterocyclic ring comprising 1-2 heteroatoms selected from N, O and S as the vertices of the cycle； and R is selected from the group consisting of C1-6alkyl, C2-6alkenyl, C1-6alkynyl and Ci-haloalkyl； A is a member selected from the group consisting of: wherein R is independently selected from the group consisting of —NRR, —OR, —CN, —NO, halogen, - C (O) OR, -C (O) NRR, -NRC (O) R, -NRS (O) R, -NRS (O) R, -S (O) R, S (O) R and -R, where R and R in each case are each independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1 haloalkyl and - (CH) phenyl, or R 2 R or R 2 and R 2 together with the atom to which each is attached form 3 A 7-membered heterocyclic ring comprising 1-2 heteroat
