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БЕНЗИЗОКСАЗОЛЫ И АЗАБЕНЗИЗОКСАЗОЛЫ КАК АЛЛОСТЕРИЧЕСКИЕ ПОТЕНЦИАТОРЫ MGLUR4, КОМПОЗИЦИИ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ ДИСФУНКЦИЙ
专利权人:
ВАНДЕРБИЛТ ЮНИВЕРСИТИ (US)
发明人:
КОНН П. Джеффри (US),ЛИНДСЛЕЙ Крейг В. (US),ХОПКИНЗ Кори Р. (US),УИВЕР Чарлз Девид (US),НИСУЭНДЕР Коллин М. (US),ЭНГЕРС Даррен В. (US)
申请号:
RU2012139491/04
公开号:
RU2012139491A
申请日:
2011.02.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A compound having the structure represented by the formula: wherein each X is independently selected from the group consisting CRi N Y is selected from the group consisting of O and S Z is selected from the group consisting CRi N W is selected from the group consisting of O and NH A is selected from C-C cycloalkyl, or C-C cycloalkenyl, or aryl, or heteroaryl, or C-heterocycloalkyl, or C-heterocycloalkenyl, or a 3-8 membered ring containing C, O, S and / or N R is selected from the group consisting of hydrogen, halogen, C-alkyl, C-nikloalkil OS-alkyl (which may contain P-membered ring containing C, O, S or N, optionally substituted with one or more R), NRR, CONRR, S (O) NRR, CN or CF are independently selected from the group consisting of hydrogen, halogen, C alkyl, C cycloalkyl, OC-alkyl (which may contain P-membered ring containing C, O, S or N, optionally substituted with one or more R), NRR, CORR, CRR, CONRR, S (O) NRR, CN, CFili S (O) C-alkyl (which may contain C-chlenpy ring containing C, O, S or N, optionally replaced enny one or more R) independently is selected from the group consisting of hydrogen, halogen, C alkyl, C cycloalkyl, OC-alkyl (which may contain P-membered ring containing C, O, S and / or N, optionally substituted with one or more R), NRR, CORR, CRR, CONRR, S (O) NRR, CN, CFili S (O) C-alkyl (which may contain P-membered ring containing C, O, S or N, optionally substituted with one or more R) r and may be the optional cyclized so as to form a ring containing C-C cycloalkyl, or C-C cycloalkenyl, or aryl or heteroaryl or C-geterotsi loalkil, or a 3-8 membered ring containing C, O, S and / or N, optionally substituted with one or more R R c is selected from c
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http://www.ckcest.cn/home/
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