Research Triangle Institute;United States of America, as represented by The Secretary, Department of Health and Human Services
发明人:
申请号:
EP11723158.9
公开号:
EP2571858B1
申请日:
2011.05.20
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
Provided herein are compounds and prodrugs and methods of preparation of compounds and prodrugs that are capable of functioning as releasers and/or uptake inhibitors of one or more monoamine neurotransmitters, including dopamine, serotonin, and norepinephrine. Also provided are pharmaceutical compositions comprising one or more of these compounds or prodrugs, which may further comprise one or more additional therapeutic agents. Also provided are methods of treatment of various conditions that may be responsive to modification of monoamine neurotransmitter levels, such as pre-obesity, obesity, addiction, and depression.