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Compositions and methods for modulating an immune response
专利权人:
President and Fellows of Harvard College
发明人:
Arlene H. Sharpe,Peter T. Sage,Loise M. Francisco
申请号:
US14707596
公开号:
US09885016B2
申请日:
2015.05.08
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune responses or both, and the use of those methods in the treatment of diseases or conditions mediated by TFR or TFH cells. The invention also provides novel methods for identifying TFR and TFH cells in a population of cells. The invention also provides compositions comprising TFR cells that have enhanced suppressive activity as compared wild type TFR cells. The invention also provides compositions comprising T follicular regulatory (TFR) cells isolated from the peripheral blood of a subject wherein the composition is enriched for TFR cells. Methods of making and using the compositions of the invention to modulate an immune response are also provided.
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