The present invention relates to compositions, methods, and uses employing lentiviral vector particles for induction of an immune response by administration to a human, wherein the lentiviral vector particles comprise a lentiviral vector, wherein the DNA of the lentiviral vector comprises a promoter directing expression of an HTLV-1 Tax and/or HBZ antigen, and/or a p12I and/or p30II antigen. The invention encompasses these vectors, methods of making the vectors, and methods of using them, including medicinal uses.
