Richard Gomer;Anu S. Maharjan;Jonathan Phillips;Sarah Herlihy;Darrell Pilling
发明人:
Richard Gomer,Jonathan Phillips,Sarah Herlihy,Anu S. Maharjan,Darrell Pilling
申请号：
US13571841
公开号：
US20130039897A1
申请日:
2012.08.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The disclosure relates to compositions including dipeptidyl peptidase-IV (DPPIV) as well as compositions including an anti-DPPIV antibody operable to bind a DPPIV region structurally homologous to a Dictyostelium autocrine proliferation repressor A (AprA) region. The disclosure also relates to a method of reducing the number of neutrophils in a body region by administering a DPPIV composition to the body region in an amount and for a time sufficient to suppress neutrophil movement into the body region or enhancing neutrophil movement out of the body region. In particular, it relates to a method of reducing the number of neutrophils in a body region suffering from an acute injury or from a chronic or long-term disease. Further, the disclosure relates to a method of increasing the number of neutrophils in a body region by administering an anti-DPPIV antibody operable to bind a DPPIV region structurally homologous to a Dictyostelium AprA region.
