Andrew Cox,Dhamodharan Neelamegan,Ian Schoenhofen,Frank St. Michael,James Richards
申请号：
US12093992
公开号：
US08975043B2
申请日:
2006.11.23
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Novel enzymes, processes and antigenic structures useful in producing vaccines and compounds useful in combating gram-negative bacteria are described. Enzymes were isolated from the slime mold Dictyostelium discoideum and used to specifically degrade lipopolysaccharide (LPS). Enzymatic degradation permits residues of the LPS molecule, including immunogenic epitopes of the core oligosaccharide portion of the LPS, to remain unmodified during this enzymatic removal of fatty acids from the lipid A region of the LPS molecule.
