AZIDOTHYMIDINE QUINOLINE CONJUGATED COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN ANTI-HEPATOMA THERAPY

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专利权人:

HUA ZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人:

ZHOU, QIBING

申请号：

CNCN2012/077030

公开号：

WO2013/123745A1

申请日:

2012.06.15

申请国别(地区):

WO

年份:

2013

代理人:

摘要：

The present invention provides an azidothymidine quinoline conjugated compound N-((l-(2-(hydroxymethyl)-5-(5-methyl-2, 4-dioxo-3, 4-dihydro-pyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl)-1H-1, 2, 3-triazol-4-yl) methyl)-6-(4b, 8, 8-trimethyl-4b, 5, 6, 7, 8, 8a, 9, 10-hexahydrodibenzo [a, c] phenazin-2-yloxy) hexanamide. The compound can be used for preparing anti-hepatoma drugs.La présente invention concerne un composé conjugué dazidothymidine quinoléine N-(1-(2-hydroxyméthyl)-5-5-méthyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)-tétrahydrofuran-3-yl-1 H-1,2,3-triazol-4-yl)méthyl)-6-(4b,8,8-triméthyl-4b,5,6,7,8,8a,9,10-hexahydrodibenzo[a,c]phénazine-2-yloxy)hexanamide. Le composé peut être utilisé pour la préparation de médicaments anti-hépatome.

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