The present invention provides acylsulfonamides including bumetanide derivatives and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these compounds and methods for their use. All of these analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl- co-transporter or GABAA receptor including but not limited to addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (autism), bipolar disorder, cancer, the improvement of cognitive function, cognitive impairment, cognitive dysfunction, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma, Huntington's Disease, inflammatory pain, insomnia, ischemia, migraine, migraine with aura, migraine without aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, Parkinson's disease, periodic limb movement disorder (PLMD), personality disorders, postherpetic neuralgia, psychosis, restless legs syndrome (RLS), schizophrenia, seizure disorders, spasticity, tinnitus, and withdrawal syndromes.本発明は、ブメタニド誘導体を含めたアシルスルホンアミド、およびこのような類似体を含む組成物を提供する。これらの類似体の全ては、嗜癖障害、アルツハイマー病、不安障害、腹水、注意欠陥多動性障害（ＡＤＨＤ）、自閉症スペクトラム障害（自閉症）、双極性障害、がん、認知機能の改善、認知機能障害、認知機能不全、うつ病、角膜内皮ジストロフィー、浮腫、てんかん、緑内障、ハンチントン病、炎症性疼痛、不眠、虚血、片頭痛、前兆を伴う片頭痛、前兆を伴わない片頭痛、神経因性疼痛、侵害受容性神経痛、侵害受容性疼痛、眼疾患、疼痛、パーキンソン病、周期性四肢運動障害（ＰＬＭＤ）、人格障害、ヘルペス後神経痛、精神病、下肢静止不能症候群（ＲＬＳ）、統合失調症、発作性障害、痙縮、耳鳴、および離脱症候群を含めた、Ｎａ＋Ｋ＋Ｃｌ－共輸送体またはＧＡＢＡＡ受容体が関与する状態の治療および／または予防のために特に有用である。
