The present invention provides acylsulfonamides including bumetanide derivatives and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these compounds and methods for their use. All of these analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl co transporter or GABAA receptor including but not limited to addictive disorders Alzheimer s Disease anxiety disorders ascites attention deficit hyperactivity disorder (ADHD) autism spectrum disorders (autism) bipolar disorder cancer the improvement of cognitive function cognitive impairment cognitive dysfunction depression endothelial corneal dystrophy edema epilepsy glaucoma Huntington s Disease inflammatory pain insomnia ischemia migraine migraine with aura migraine without aura neuropathic pain nociceptive neuralgia nociceptive pain ocular diseases pain Parkinson s disease periodic limb movement disorder (PLMD) personality disorders postherpetic neuralgia psychosis restless legs syndrome (RLS) schizophrenia seizure disorders spasticity tinnitus and withdrawal syndromes.
